Information om | Engelska ordet FRAMESHIFT

Exempel på hur man kan använda FRAMESHIFT i en mening

• alt=Drawing of a gene showing kinds of defects (missing promoter, start codon or introns, premature stop codon, frameshift mutation, partial deletion).
• A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three.
• The mutants produced by Crick and Brenner that could not produce functional rIIB protein were the results of frameshift mutations, where the triplet code was disrupted.
• Usually, insertions and the subsequent frameshift mutation will cause the active translation of the gene to encounter a premature stop codon, resulting in an end to translation and the production of a truncated protein.
• In mice, a Foxp3 mutation (a frameshift mutation that result in protein lacking the forkhead domain) is responsible for 'Scurfy', an X-linked recessive mouse mutant that results in lethality in hemizygous males 16 to 25 days after birth.
• An indel change of a single base pair in the coding part of an mRNA results in a frameshift during mRNA translation that could lead to an inappropriate (premature) stop codon in a different frame.
• J-Lat contains integrated but transcriptionally latent HIV proviruses, in which GFP replaces nef coding sequence, and a frameshift mutation in env.
• This frameshift is stimulated by a pseudoknot present 3' of the frameshift site in the antizyme mRNA.
• The HIV-1 ribosomal frameshift signal requires two cis-acting elements: a heptameric "slippery site" and a downstream secondary RNA structure separated by an 8-nucleotide spacer.
• This prevents BioBricks from being used to create fusion proteins, as the 6bp scar sequence codes for a tyrosine and a stop codon, causing translation to be terminated after the first domain is expressed, while the 8bp scar sequence causes a frameshift, preventing continuous readthrough of the codons.
• Congenital dysfibrinogenemia is most often caused by a single autosomal dominant missense mutation in the Aα, Bβ, or γ gene; rarely, it is caused by a homozygous or compound heterozygous missense mutation, a deletion, frameshift mutation, insert mutation, or splice site mutation in one of these genes.
• High levels of polyamines induce a +1 ribosomal frameshift in the translation of mRNA for the antizyme leading to the expression of a full-length protein.
• Scores of different types of inactivating GATA mutations have been associated with GATA2 deficiency; these include frameshift, point, insertion, splice site and deletion mutations scattered throughout the gene but concentrated in the region encoding the GATA2 transcription factor's C-ZnF, N-ZnF, and 9.
• In the case where a frameshift results in nonsense, the nonsense-mediated mRNA decay (NMD) pathway may destroy the mRNA transcript, so frameshifting would serve as a method of regulating the expression level of the associated gene.
• Arboleda-Tham syndrome (ARTHS), also referred to as KAT6A Syndrome (Arboleda-Tham Syndrome), is a rare autosomal dominant developmental disorder, caused by various missense, nonsense, and frameshift mutations in the KAT6A gene.
• Another patient with a frameshift HERC1 mutation predicted to truncate the protein displayed facial dysmorphism, macrocephaly, epileptiform discharges, hypotonia, intellectual disability, and autistic features.
• Yersinia pestis contains genes relating to aerobactin, but they have been inactivated by a frameshift mutation, thus Y.
• For instance a frameshift mutation or a missense mutation at the DCX gene location causes a neuronal migration defect also known as lissencephaly.
• Depending on the host species, two different strategies can be used to express the two polyproteins: a fusion into a single open reading frame (ORF) that is then cleaved or the introduction of a frameshift between the two ORFs.
• The main differences between PairWise and other alignment algorithm is that, besides normal penalties such as Gap Opening Penalty (GOP), Gap Extension Penalty (GEP) and Match, PairWise introduced two new penalties called Frame Opening Penalty (FOP) and Frame Extension Penalty (FEP), which will be incurred when a frameshift is accepted and extended respectively.

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