Anagram & Information om | Engelska ordet MHC

Exempel på hur man kan använda MHC i en mening

• Histocompatibility, or tissue compatibility, is the property of having the same, or sufficiently similar, alleles of a set of genes called human leukocyte antigens (HLA), or major histocompatibility complex (MHC).
• If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen, and the T cell destroys the cell.
• The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system.
• The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals.
• Human leukocyte antigen (HLA) B27 (subtypes B*2701-2759) is a class I surface molecule encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells.
• There are three general methods in which an organization might demutualize, full demutualization, sponsored demutualization, and into a mutual holding company (MHC).
• He and Rolf Zinkernagel, the co-recipient of the 1996 Nobel Prize in Physiology or Medicine, discovered how T cells recognise their target antigens in combination with major histocompatibility complex (MHC) proteins.
• The first single, "Crazy", released on 26 September 2005, included club remixes from his Erasure partner Vince Clarke, plus Cicada, MHC and King Roc.
• With the exception of non-nucleated cells (including erythrocytes), all cells are capable of presenting antigen through the function of major histocompatibility complex (MHC) molecules.
• Zinkernagel and Doherty discovered that for killer T-cells to recognize infected cells, they had to recognize two molecules on the surface of the cell—not only the virus antigen, but also a molecule of the major histocompatibility complex (MHC).
• The partially folded MHC class I molecule then interacts with TAP via tapasin (the complete complex also contains calreticulin and Erp57 and, in mice, calnexin).
• Most cells in the body can present antigen to CD8+ cytotoxic T cells via MHC class I; however, the term "antigen-presenting cell" is often used specifically to describe professional APCs.
• T cells displaying CD4 molecules (and not CD8) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted).
• MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of vertebrates.
• The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
• It is believed that MHC I loading occurs both in the ER as well as phagocytic vesicles such as an endosome in the cytosolic pathway.
• Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the MHC class I protein.
• In order for lymphocytes such as T cells to become immunocompetent, which refers to the ability of lymphocyte cell receptors to recognize MHC molecules, they must undergo positive selection.
• TCR of conventional T cells must be able to recognize parts of major histocompatibility complex (MHC) molecules (MHC class I in case of CD8+ T cells or MHC class II in case of CD4+ T cells) to create proper interaction with antigen-presenting cell.
• The CD4 or CD8 proteins on the T-cell surface form a complex with the CD3 protein, which can then recognize the MHC.

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