Information om | Engelska ordet NUCLEOSIDES

Exempel på hur man kan använda NUCLEOSIDES i en mening

• Nucleotide bases (also nucleobases, nitrogenous bases) are nitrogen-containing biological compounds that form nucleosides, which, in turn, are components of nucleotides, with all of these monomers constituting the basic building blocks of nucleic acids.
• The analog is one of the five standard nucleosides which make up nucleic acids, the others being adenosine, thymidine, cytidine and guanosine.
• Alexander Robertus Todd, Baron Todd (2 October 1907 – 10 January 1997) was a British biochemist whose research on the structure and synthesis of nucleotides, nucleosides, and nucleotide coenzymes gained him the Nobel Prize for Chemistry in 1957.
• Some common examples of secondary metabolites include: ergot alkaloids, antibiotics, naphthalenes, nucleosides, phenazines, quinolines, terpenoids, peptides and growth factors.
• Also RNA molecules often contain posttranscriptionally modified nucleosides, which because of new possible non-canonical interactions, cause a lot of troubles for tertiary structure prediction.
• This name remained in use throughout much of the work to characterize the compound, after which it was proposed that its common name should be based on the sound of the letter Q—thus producing "queuine" by analogy to guanine and other nucleobases, and "queuosine" by analogy to guanosine and other nucleosides.
• Currently, the process is implemented as solid-phase synthesis using phosphoramidite method and phosphoramidite building blocks derived from protected 2'-deoxynucleosides (dA, dC, dG, and T), ribonucleosides (A, C, G, and U), or chemically modified nucleosides, e.
• More specifically, dCK adds the first phosphoryl group to preformed nucleosides and is usually the rate-limiting enzyme of the overall process of converting nucleosides to their deoxynucleoside triphosphate form, or nucleotide form, in the nucleoside salvage pathway.
• The compounds are prepared by attaching the borane to the phosphoramidite stage in the synthesis of nucleosides.
• Intriguingly, the biomolecules most damageable by this type of damage belong to the group of essential nutrients (10 out of 20 amino acids; nucleosides at certain conditions (conditionally essential); all polyunsaturated fatty acids).
• Nucleoside-specific porin (the tsx gene of Escherichia coli) is an outer membrane protein, Tsx, which constitutes the receptor for colicin K and Bacteriophage T6, and functions as a substrate-specific channel for nucleosides and deoxy-nucleosides.
• NTC53 catalyzes the dephosphorylation of the pyrimidine 5′ monophosphates UMP and CMP to the corresponding nucleosides.
• Potential treatments include prosultiamine, a vitamin B-1 derivative, which has been shown to reduce viral load and symptoms; azacytidine, an anti-metabolite, which has been credited with the cure of a patient in Greece; tenofovir disoproxil (TDF), a reverse-transcriptase inhibitor used for HIV; cepharanthine, an alkaloid from stephania cepharantha hayata; and phosphonated carbocyclic 2'-oxa-3'aza nucleosides (PCOANs).
• Synthesis of unnatural carbohydrate analogs (bridged deoxyfuranosids and furanoses, disaccharides, nucleosides, glycolipids).
• thesis, Youvan found inhibitors (hypermodified nucleosides) of retroviral reverse transcriptase present in ribosomal RNA.
• Vince lactam has been extensively used for the preparation of various carbocyclic nucleosides with medicinal applications in mind, including carbocyclic puromycin (I), carbocyclic Ara-A (II), carbovir (III) and guanine as well as azaguanine carbocyclic derivatives (IV).
• Proteins catabolize into amino acids, and amino acids are precursors for purines, nucleotides and nucleosides which are used in the purine nucleotide cycle.
• Wybutosine and other unnatural nucleosides have been proposed to lead to a single outcome of hypermodification.
• This protein can degrade all purine nucleosides (including xanthosine) except adenosine, deoxyadenosine, hypoxanthine arabinoside.
• His scientific career started in 1970 at the Salk Institute for Biological Sciences in La Jolla with working in the field of nucleic acid chemistry and biochemistry on unique chemical substitutions in nucleosides, nucleotides, and polynucleotides as potential anti-viral and anti-cancer agents.

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